Ethoxylated hydrogenated castor oil
Ethoxylated hydrogenated castor oil
CAS: 61788-85-0
Molecular Formula:
Ethoxylated hydrogenated castor oil - Names and Identifiers
| Name | Ethoxylated hydrogenated castor oil |
| Synonyms | hco40 hco50 cremophorrh40 Emulsifier HEL |
| CAS | 61788-85-0 |
| EINECS | 918-326-5 |
Ethoxylated hydrogenated castor oil - Physico-chemical Properties
| Density | 0.983[at 20℃] |
| Boling Point | 348℃[at 101 325 Pa] |
| Flash Point | 242℃ |
| Water Solubility | 500μg/L at 20℃ |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Light yellow liquid to paste |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | For the emulsification of organophosphorus pesticides and pharmaceutical, ink emulsifier, is also one of the components of fiber oil agent, emulsification and antistatic effect |
| In vivo study | 20% PEG-40 hydrogenated castor oil (10 μl) is applied to the left ear of the mouse, and the right ear served as a control. The mice are observed for development of erthyma for 6 days, no signs of irritation are observed in the mice.PEG-40 hydrogenated castor oil (injection via the tail vein; 300, 900, and 2700 mg/kg; 4 weeks) is administared for short-term toxicity. At doses of 300 and 900 mg/kg PEG-40 Hydrogenated Castor Oi exhibits no systemic toxicity. However, at a dose of 2700 mg/kg, slight ataxia is observed and body weight is reduced significantly in the males and slightly in the females.A toxicity study of blank nanoemulsion using PEG-40 hydrogenated castor oil as a surfactant is applied in order to load various active compounds for oral administration.Nearly 20% of PEG-40 hydrogenated castor oil was used to emulsify the glyceryl monooleate (GMO) as an oil to the aqueous phase. In Webster mice, 5000 mg/kg blank nanoemulsion is given orally to mice once a day for 14 days, this nanoemulsion does not produce hazardous effects, and it has no effect on food intake. |
Ethoxylated hydrogenated castor oil - Risk and Safety
| WGK Germany | 1 |
Ethoxylated hydrogenated castor oil - Reference
| Reference Show more | 1. [IF=2.952] Yulin Liang et al."Preparation and quality evaluation of a volatile oil microemulsion from Flos magnoliae and Centipeda minima."Mol Med Rep. 2020 Dec;22(6):4531-4540 2. [IF=2.563] Wang Yunhong et al."Oil–water partition coefficient preparation and detection in the dihydroartemisinin self-emulsifying drug delivery system."BMC BIOTECHNOLOGY. 2022 Dec;22(1):1-9 |
Ethoxylated hydrogenated castor oil - Nature
Open Data Verified Data
light yellow paste. Soluble in water, soluble in fatty acids, oils, mineral oil and a variety of organic solvents. Acid-resistant, hard water-resistant, resistant to inorganic salts, alkali-resistant at low temperature, and hydrolysis in case of strong alkali. Has excellent emulsifying properties.
Last Update：2024-01-02 23:10:35
Ethoxylated hydrogenated castor oil - Preparation Method
Open Data Verified Data
The refined Castor oil is obtained by condensation with ethylene oxide under the action of a catalyst.
Last Update：2022-01-01 09:28:33
Ethoxylated hydrogenated castor oil - Use
Open Data Verified Data
can be used as emulsifier, filler, solubilizer, wetting agent, defoaming agent, etc. Used in cosmetics, printing ink and pesticides as emulsifier; Textile industry as chemical fiber oil agent, in the chemical fiber slurry as soft and smooth agent, can eliminate the foam of synthetic slurry; Can be used as demulsifier oil field crude oil dehydration; used as fatliquor in the leather industry.
Last Update：2022-01-01 09:28:34
Ethoxylated hydrogenated castor oil - Safety
Open Data Verified Data
non-toxic.
Last Update：2022-01-01 09:28:34
Ethoxylated hydrogenated castor oil - Reference Information
| LogP | 8 at 25℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| hydrogenated castor oil | the appearance of hydrogenated castor oil is light yellow to yellow, viscous non-drying oil, refractive index (25 ℃) is 1.475~1.488, acid value is φ5, saponification value is 176~187, iodine value is 83~89g/156g, Hydroxyl value is 165 ~ mg KOH/gOil, viscosity (25 ℃) 680MPa▪s, the relative density of 1.023. Wherein hydrogenated ricinoleic acid is an important component of hydrogenated castor oil, the system is named 12-hydroxystearic acid, the English name is 12-hydroxystearic acid, the molecular formula is, the molecular weight is 300.477, the CAS number is 36377-33-0. hydrogenated castor oil can be used as a lubricant for tablets. Although its lubricating effect is not as good as that of magnesium stearate, hydrogenated castor oil is the best choice for a small number of tablets that produce sticking in the tableting process, for example, it is desirable to use hydrogenated castor oil as a lubricant Clopidogrel Hydrogen Sulphate Tablets. In fact, most drugs with strong polarity (drugs with strong hydrophilicity) and drugs that are easy to cause mottling in the process of tableting can be used as a lubricant in hydrogenated castor oil, which can play a lubricating role, can also prevent the role of sticking, can also play a hydrophobic role is not easy to produce mottling. Hydrogenated castor oil is generally used as a lubricant by external method, and the dosage is generally 0.2%-2%. PEG-60 hydrogenated castor oil is a commonly used high-efficiency solubilizing agent, which can uniformly disperse oily substances such as essence and essential oil into water to form a stable and transparent solution. PEG-40 hydrogenated castor oil solubilizer is a viscous liquid or paste; It is an excellent non-ionic solubilizer and emulsifier; It has wide pH stability, low foam, A clear mixture can be formed with acids and alcohols at elevated temperatures. It can be used in water or alcohol solution to solubilize essential oils and synthetic perfumes. When in use, the product and the substance to be solubilized can be mixed in a ratio of 1:1-3 and stirred evenly until transparent. Can be used as a medical grade solubilizer. |
| Overview | the functional groups in the molecular structure of castor oil determine that it can undergo a variety of chemical reactions to produce numerous derivatives, and most of them are important fine chemicals. Hydrogenated castor oil is one of the derivatives of castor oil, with stable performance and high melting point. It is widely used in cosmetics. The reaction product with the hydroxide file is a file-based lubricating oil, which is widely used in the aviation industry, automobile manufacturing and mechanical processing industries, and has a large demand in the domestic and foreign markets. In addition, hydrogenated castor oil can be used as a base material for various chemical reactions or unit processing, and is prone to cracking, unitary, phthalic amination, sulfonation, halogenation, saponification, hydrolysis, epoxidation and ethoxylation and other chemical reactions, derivatives of a wide range of applications. |
| Application | hydrogenated castor oil plays a role in thickening, hardening and sustained release in the preparation, so it is used as thickener, stiffener and sustained release agent, for the preparation of semi-solid preparations and solid preparations, such as ointments, suppositories, pills, tablets, etc. In ointments, creams and suppositories, it is mainly used as a hardening agent of the paste for adjusting the consistency of the preparation; In oral preparations, it is mainly used for the preparation of sustained-release tablets and capsules, it can be used as a coating film or form a solid skeleton, and play a role of sustained release or Controlled Release. It can also be used as a lubricant for tablets and capsules to improve the fluidity of the granules. |
| biological activity | ethylene hydroxy castor oil (PEG-40 hydroxy castor oil) is polyethylene glycol (PEG) mixture with natural castor oil. Ethoxylated hydronic castor oil can be used for emulsification and solubilization of oil-in-water (o/w) emulsions. Ethoxylated hybrid castor oil can be used as a co-solvent in animal experiments. |
| Use | used in the production of daily cosmetics, shoe polish, pharmaceutical ointment, is the preparation of 12-hydroxystearic acid raw material |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intravenous injection-mouse LD50: 5000 mg/kg |
| flammability hazard characteristics | thermal decomposition of spicy and irritating smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | fog water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 21:32:07
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